Coronavirus: UK hospital trials new treatment drug
BBC:A new drug developed by UK scientists to treat Covid-19 patients is being trialled at University..
BBC:A new drug developed by UK scientists to treat Covid-19 patients is being trialled at University Hospital Southampton.
Developed by UK bio-tech company Synairgen, it uses a protein called interferon beta, which our bodies produce when we get a viral infection.
Initial results from the trial are expected by the end of June.
There are currently few effective treatments for coronavirus with doctors relying on patients’ immune systems.
What is the new drug?
Interferon beta is part of the body’s first line of defence against viruses, warning it to expect a viral attack, explains Richard Marsden, chief executive of Southampton-based Synairgen.
He says the coronavirus seems to suppress its production as part of its strategy to evade our immune systems.
The drug is a special formulation of interferon beta delivered directly to the airways when the virus is there, with the hope that a direct dose of the protein will trigger a stronger anti-viral response even in patients whose immune systems are already weak.
- When will we have a drug to combat coronavirus?
- How long does it take to recover?
- Coronavirus: What it does to the body
Interferon beta is commonly used in the treatment of multiple sclerosis.
Synairgen has already shown its preparation can stimulate the immune response in the lungs of patients with asthma and other chronic lung conditions.
But we can only know whether it works for Covid-19 patients after it has been through a rigorous clinical trial.
Kaye Flitney is one of 75 people who have been enrolled in the clinical trial, filmed exclusively by BBC Panorama. It requires Covid-19 patients, like her, to inhale the drug via a nebuliser to bring it deep into the lungs.
Kaye, 67, struggles to sit up in her hospital bed and coughs as she puts the dispenser to her lips. She says when she first found out she had coronavirus her first thought was not for her own health.
“I was frightened because my husband has heart failure. It would kill him.”
The 67-year-old, who was taken to hospital due to difficulty with her breathing, said taking the drug hasn’t caused her much discomfort.
“You don’t notice you’re taking it ’til you’re finished. It’s not so bad. I could see myself taking it at home.”
How does the trial work?
The 75 volunteers involved so far have been recruited from some 10 hospitals around Britain. Half get the drug, half get what is known as a placebo – an inactive substance.
No-one involved in the trial knows which patients have been given which treatment until the trial is over.
“If you know it’s a drug, your mind might have a bias,” explains Sandy Aitken, the nurse administering the drug.
The hope is, it will show the patients getting the drug do much better than those that don’t, says Professor Tom Wilkinson, of the University of Southampton.
Synairgen’s drug trial is the template for a new fast-track clinical scheme that has just been set up by the government.
The Accord programme, as it is known, is designed to accelerate the development of new drugs for patients with Covid-19.
The first phase of the programme involves six other drugs.
More than 100 treatments are being explored worldwide and a drug called remdesivir, which was developed as an Ebola treatment, has generated particular excitement.
US officials have claimed there is “clear-cut” evidence it helps people recover from the coronavirus.
How far away could the UK treatment be?
Initial results from the interferon beta trial are expected by the end of June. But even if the drug does show promise, it will face further scrutiny before it can be used routinely on patients.
That could take months, although the government has said it will work as fast as possible.
If deemed effective, the drug and the nebulisers used to deliver it would then need to be manufactured in huge quantities.
Mr Marsden says he is already talking to suppliers around the world about whether it will be possible to start producing the drug as soon as the clinical trial is over.
However, he says it would still not be widely available until the end the year.
Strategic Twinning of Rabat And Madrid: A Defense Against Mediterranean Tension
Rabat – The writer-journalist, Abdelhamid Jmahri believes that the wish today of Morocco and Spain, after the clarification of the foundations of their cooperation, is to establish a geostrategic twinning that goes beyond the limits of close cooperation and privileged partnership, thus blocking the way to maneuvers aimed at exacerbating tensions in the Mediterranean region.
Al Itihad Al Ichtiraki”
In an editorial to appear in the Saturday edition of the Arabic-language daily “Al Itihad Al Ichtiraki”, he notes that this ambition is clearly displayed through the will of HM King Mohammed VI in His call to inaugurate “a new unprecedented stage ” and also that of King Felipe VI of Spain calling for weaving partnership relations for the 21st century.
He maintains that the High Level Meeting (RHN) held last Thursday in Rabat is the bearer of strategic partnerships specific to countries concerned with a perfect understanding of their common interests and also sharing the same conception of the interactions of international action, at the present time. as in the future.
While emphasizing that the two Kingdoms have set a living example on the priority nature of the conciliatory diplomatic approach and its supremacy in the settlement of disputes, he observes that the agreements signed during this High Level Meeting relate to key sectors targeted , in support of a common understanding of priorities.
This article is originally published on msn.com
Spain-Morocco Reconnection: Post-Crisis Efforts
After a deep diplomatic crisis, Spain and Morocco cemented their reconciliation on Thursday in Rabat, despite criticism in Madrid over too many concessions from Prime Minister Pedro Sanchez.
Mr. Sanchez, accompanied by a dozen ministers, co-chaired a “high-level meeting” (RHN) with his counterpart Aziz Akhannouch, the first since 2015.
“Today we are consolidating the new stage in relations between Morocco and Spain that we have opened,” he said, praising “the enormous unexplored potential of this relationship”.
Before his arrival in Rabat on Wednesday, the Socialist Prime Minister spoke by telephone with King Mohammad VI who invited him to return “very soon” to Morocco for an official visit “in order to reinforce this positive dynamic”, according to the royal cabinet.
Mr. Sanchez ended last March a year of diplomatic estrangement with Morocco by agreeing to support Moroccan positions on Western Sahara.
The crisis erupted in April 2021 after the hospitalization in Spain – under a false identity according to Rabat – of the leader of the Sahrawi separatists of the Polisario Front, Brahim Ghali, sworn enemy of Morocco.
The Rabat-Madrid honeymoon comes as France – another historical partner of Rabat – is pilloried by Moroccan politicians and media who accuse it of having “orchestrated” a European Parliament resolution worrying about freedom of the press in Morocco and allegations of corruption of MEPs in Brussels.
But this idyll is not to everyone’s taste in Spain. The radical left formation Podemos, member of the government coalition, did not wish to be on the trip to Rabat, citing its opposition to Mr. Sanchez’s “unilateral” turn on Western Sahara. A turnaround applauded in Rabat.
The fact that Mr. Sanchez was not received by Mohammad VI is seen as a snub in Spain by the right-wing opposition and the press. The Popular Party, the main opposition force, deplored Thursday, through the voice of its general coordinator Elias Bendodo, that “Spain has given an image of weakness”.
“The absence of Mohammad VI spoils the summit”, wrote the daily El Païs (center left) while the newspaper El Mundo (conservative) headlined: “Mohammad VI shows his position of strength with regard to Spain by posing a rabbit to Sanchez”.
New Economic Partnership
Pedro Sanchez said he hoped for the development of “new investment projects accompanying the extraordinary process of development and modernization of Morocco”. “Morocco and Spain wish to establish a new economic partnership at the service of development”, underlined for his part Mr. Akhannouch.
Twenty agreements were signed on Thursday to facilitate Spanish investment in Morocco – Spain is the third largest foreign investor there – in the fields of renewable energies, water desalination, rail transport, tourism , education and culture. To this end, a new financial protocol has been approved which will double – to 800 million euros – aid from the Spanish government for investment projects in Morocco.
Also in the pipeline is an agreement to “completely normalize the passage of people and goods” through sea and land borders. The opening of land crossings concern the Spanish enclaves of Melilla and Ceuta, in northern Morocco.
Without forgetting the files of illegal immigration and the fight against terrorism. Madrid highlighted the drop of more than 25% in illegal immigration in 2022 thanks to its police cooperation with Rabat, with 31,219 migrants entering Spain illegally in 2022.
This cooperation, welcomed by Rabat, was however tarnished by the death of at least 23 Sudanese migrants who had tried last June to enter the enclave of Melilla via the Moroccan border town of Nador.
The Minister of the Interior, Fernando Grande-Marlaska, was also to plead with his Moroccan counterpart, Abdelouafi Laftit, to reactivate the channels for the expulsion of irregular migrants and return to levels prior to the Covid-19 pandemic. , according to a source from the Spanish ministry.
Finally, Rabat is considered a key partner in the fight against terrorism. An important subject for Madrid after an attack at the end of January attributed to a young Moroccan in an irregular situation against two churches in Algeciras (South) in which a sexton was killed.
This article is originally published on lorientlejour.com
Morocco-Spain Partnership for 21st Century Challenges
Madrid – Aware of the strategic importance of preserving and developing a privileged relationship looking to the future, Morocco and Spain show a firm determination to build a renewed global partnership, up to the challenges but also opportunities offered by the 21st century, said Morocco’s ambassador to Spain, Karima Benyaich.
Both Countries Are Neighboring And Friendly
“Morocco and Spain are two friendly and neighboring countries, which share common values and interests and which continue to work together to make their relationship an example to follow in all areas,” said Ms. Benyaich in an interview with MAP, on the occasion of the holding in Rabat of the 12th Morocco/Spain High Level Meeting.
It is within the framework of this spirit that fits the speech delivered by HM King Mohammed VI on the occasion of the 68th anniversary of the Revolution of the King and the People, on August 20, 2021, in which the Sovereign called for the inauguration of an unprecedented stage in relations between the two countries, based on mutual trust, permanent consultation and frank and sincere cooperation, recalled Ms. Benyaich.
Responding to the generous appeal of HM the King, the Spanish government has repeatedly reaffirmed its unshakeable will to engage with Morocco in a renewed dynamic to establish a lasting relationship on more solid foundations, observed the Diplomat.
”Today, in accordance with this new dynamic initiated between the two countries since last April, following the visit of the President of the Spanish Government, Pedro Sanchez, to Morocco, at the invitation of HM the King and the adoption of an ambitious roadmap, Morocco and Spain are determined to move forward in the implementation of this virtuous process, by identifying all the appropriate means to give this partnership a serene, lasting basis and an operational character. which will strengthen bilateral relations and create mutually beneficial synergies,” noted Ms. Benyaich in this regard.
In this wake, the Ambassador of Morocco to Spain highlighted the “excellent relations of brotherhood” uniting the two Royal Families, assuring that the “distinguished and privileged ties of solid friendship and mutual esteem between HM the King and King Felipe VI strongly contribute to the consolidation of a unique and exemplary relationship.
Thus, argued Ms. Benyaich, the High Level Meeting between the two countries, which has not taken place since 2015, will undoubtedly constitute an exceptional meeting which will imbue a new dynamic in bilateral relations and will reflect the determination to build a mutually beneficial strategic partnership, under the enlightened leadership of His Majesty King Mohammed VI and King Felipe VI of Spain.
This meeting, she added, is only the concretization of the firm will of the two countries to take an unprecedented step in bilateral relations, on the basis of a clear and ambitious roadmap responding to the aspirations of both friendly peoples.
In this context, the leaders of the two countries are looking into the implementation of concrete actions within the framework of this roadmap encompassing all areas of the partnership and integrating all issues of common interest, in a climate of trust and transparency, said Ms. Benyaich, recalling that, since last April, all the working groups have held regular meetings to put in place the provisions of the new bilateral roadmap.
As a result, the High-Level Meeting in Rabat will reflect this positive state of mind and oriented towards respect for the commitments that drive the Moroccan-Spanish relationship today, Ms. Benyaich concluded.
This article is originally published on mapexpress.ma
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