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Coronavirus: Oxford University to resume vaccine trial after pause

Trials of a Covid-19 vaccine being developed by AstraZeneca and Oxford University will resume after ..

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Trials of a Covid-19 vaccine being developed by AstraZeneca and Oxford University will resume after being paused due to a reported side effect in a patient in the UK.

On Tuesday, AstraZeneca said the studies were being paused while it investigated whether the adverse reaction was linked with the vaccine.

But on Saturday, the university said it had been deemed safe to continue.

Health Secretary Matt Hancock welcomed the news that the trials would resume.

"This pause shows we will always put safety first. We will back our scientists to deliver an effective vaccine as soon as safely possible," he added.

The university said in a statement that it was "expected" that "some participants will become unwell" in large trials such as this one.

It added that the studies could now resume following the recommendations of an independent safety review committee and the UK regulator, the Medicines and Healthcare Products Regulatory Agency.

It would not disclose information about the patient's illness for confidentiality reasons, but the New York Times reported that a volunteer in the UK trial had been diagnosed with transverse myelitis, an inflammatory syndrome that affects the spinal cord and can be caused by viral infections.

The World Health Organization (WHO) says nearly 180 vaccine candidates are being tested around the world but none has yet completed clinical trials.

Hopes have been high that the vaccine might be one of the first to come on the market, following successful phase 1 and 2 testing.

Its move to Phase 3 testing in recent weeks has involved some 30,000 participants in the US as well as in the UK, Brazil and South Africa. Phase 3 trials in vaccines often involve thousands of participants and can last several years.

The government's chief scientific adviser, Sir Patrick Vallance, told the Downing Street press conference on Wednesday what had happened in the Oxford trial was not unusual.

Risk of 'losing control'

The news comes after Prof Sir Mark Walport, a member of the government's scientific advisory group Sage, warned the UK was "on the edge of losing control of the virus".

He told BBC Radio 4's Today programme: "You've only got to look across the Channel to see what is happening in France and what's happening in Spain."

Official figures released on Saturday showed a further 3,497 people have tested positive with the virus in the UK. It is the second day in a row that number of daily reported cases has exceeded 3,000.

It brings the overall number of confirmed cases so far to 365,174. Meanwhile, the government figures revealed that a further nine people have died within 28 days of testing positive for Covid-19, bring the UK death toll to 41,623.

Official figures indicate the UK's coronavirus epidemic is growing again, after the R number – the reproduction rate of the virus – was raised to between 1 and 1.2 for the first time since March.

Meanwhile, daily coronavirus cases in Scotland havRead More – Source

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Belize declared free from malaria by health chiefs

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The World Health Organization (WHO) has certified Belize as free of malaria.

The WHO said the Central American nation had “achieved a dramatic reduction” in malaria cases, down from 10,000 in 1994 to zero indigenous cases in 2019.

It said Belize’s achievement would serve as an inspiration for other countries in the Americas, where malaria is endemic.

Malaria, spread to humans by some types of mosquitoes, can be lethal.

The WHO said that Belize had kept the fight against malaria at the forefront of its public health agenda,

It praised the country for distributing mosquito nets treated with insecticide and encouraging the spraying of insecticides indoors.

The organisation also said that trained community health workers had “played a vital role in timely diagnosis and treatment” of malaria.

The WHO certifies a nation as malaria-free when it has shown “with rigorous, credible evidence” that the there has been no transmission of malaria within the country for at least three consecutive years.

Belize is the third country in the world to be certified this year so far, after Azerbaijan and Tajikistan.

 

Read from: https://www.bbc.com/news/world-latin-america-65974440

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How does overeating affect the immune system?

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Overeating is a common problem that affects millions of people worldwide. While it is widely understood that excessive eating leads to obesity and other health problems, many people are unaware of the impact that overeating has on the immune system. In this article, we will explore how overeating affects the immune system and what can be done to prevent or mitigate the damage.

The immune system is the body’s defense mechanism against harmful substances and infections. It is responsible for identifying and eliminating harmful pathogens and other invaders that may cause harm to the body. When the body is functioning normally, the immune system works efficiently to keep us healthy. However, when the body is subjected to chronic stress, such as from overeating, it can become weakened, making it less effective at protecting the body against illness and disease.

One of the ways in which overeating affects the immune system is by increasing inflammation. Inflammation is a natural response of the body to injury or infection, but when it becomes chronic, it can have a negative impact on the immune system. Chronic inflammation is associated with a range of health problems, including heart disease, diabetes, and certain types of cancer. When the body is constantly exposed to high levels of glucose and other harmful substances as a result of overeating, it can lead to chronic inflammation, which can weaken the immune system and increase the risk of illness.

Another way in which overeating affects the immune system is by altering the gut microbiome. The gut microbiome is the collection of microorganisms that live in the digestive tract and play a crucial role in maintaining good health. When the body is exposed to a high-fat diet, the balance of gut bacteria can become disrupted, leading to the overgrowth of harmful bacteria and the suppression of beneficial bacteria. This can result in decreased gut function and reduced immune function, making it more difficult for the body to protect itself against harmful pathogens.

In addition, overeating can also lead to obesity, which is a major risk factor for a range of health problems, including heart disease, diabetes, and certain types of cancer. Obesity is associated with a range of physiological changes, including insulin resistance and the release of cytokines, which are signaling molecules that play a crucial role in the immune response. When the body is constantly exposed to high levels of cytokines, it can lead to a state of chronic inflammation, which can weaken the immune system and increase the risk of illness.

Finally, overeating can also affect the immune system by causing oxidative stress. Oxidative stress occurs when the body is exposed to an excessive amount of free radicals, which are highly reactive molecules that can cause damage to cells and tissues. When the body is constantly exposed to high levels of glucose and other harmful substances as a result of overeating, it can lead to oxidative stress, which can weaken the immune system and increase the risk of illness.

In conclusion, overeating can have a profound impact on the immune system. By increasing inflammation, altering the gut microbiome, causing obesity, and inducing oxidative stress, overeating can weaken the body’s ability to protect itself against harmful pathogens and other invaders. To maintain a healthy immune system, it is important to eat a balanced diet, engage in regular exercise, and avoid overeating. By taking these simple steps, you can help protect your immune system and reduce your risk of illness and disease.

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Homelessness and mental illness are two intertwined issues that have a complex relationship. Homelessness can cause or worsen mental illness and, conversely, mental illness can contribute to homelessness. It is a vicious cycle that can be difficult to escape, and it is important to understand the ways in which these two issues are interconnected.

Homelessness can have a significant impact on a person’s mental health. Living on the streets can be a traumatic experience, with a constant fear of violence, theft, and disease. Homeless individuals often face stigma, discrimination, and a lack of privacy, which can lead to feelings of shame, hopelessness, and isolation. The stress and unpredictability of homelessness can trigger or exacerbate mental health problems, including depression, anxiety, and post-traumatic stress disorder (PTSD).

Mental illness, on the other hand, can also contribute to homelessness. Mental illness can make it difficult for individuals to maintain employment, manage their finances, and maintain stable housing. Individuals with mental illness may struggle with accessing treatment and support, and the stigma and discrimination associated with mental illness can also contribute to feelings of shame and isolation. These challenges can lead to a cycle of homelessness and mental illness, where each issue exacerbates the other.

There is a need for a coordinated and comprehensive approach to addressing homelessness and mental illness. This includes providing safe and stable housing, access to mental health treatment and support, and addressing the underlying social determinants of health that contribute to homelessness, such as poverty, lack of education and job opportunities.

Housing First, a program that prioritizes providing permanent housing to homeless individuals before addressing any other issues, has been shown to be effective in reducing homelessness and improving mental health outcomes. This approach recognizes that stable housing is a critical foundation for addressing other issues, including mental health.

In conclusion, homelessness and mental illness are complex and interrelated issues that require a comprehensive and coordinated approach to address. Providing stable housing and access to mental health treatment and support is critical for breaking the cycle of homelessness and mental illness and improving outcomes for individuals experiencing these issues. It is important to continue to address the root causes of homelessness, including poverty and lack of access to education and employment opportunities, to reduce the prevalence of homelessness and improve outcomes for those experiencing it.

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