A promising Australian candidate for a coronavirus vaccine has been abandoned after trial participants returned false HIV positive results.
Australia had previously agreed to buy 51 million doses of the vaccine being developed by Australian firm CSL and the University of Queensland (UQ).
The government said orders of other vaccines would now fill the shortfall.
CSL and UQ stressed that the positive results were false – meaning trial participants’ health was not at risk.
The Australian government said it had now entered an agreement for the Novavax vaccine, and upped its existing order of the Oxford/AstraZeneca vaccine.
The UK was the first to begin rolling out a vaccine from Pfizer this week.
What happened with the UQ/CSL vaccine?
The vaccine had been in stage one of trials, and proving to be effective in making antibodies.
But it also generated HIV antibodies in some recipients – which meant it showed false positives for HIV. Further testing proved the HIV wasn’t there.
CSL and UQ said fixing the flaw would take about a year, prompting a decision to abandon the trial.
“It was likely to work. But we knew that we didn’t want to have any issues with confidence, and this false-positive test may have caused some confusion and lack of confidence,” said Brendan Murphy, secretary of Australia’s Department of Health.
Vaccine co-lead Paul Young described the decision as “devastating” after 11 months of “living and breathing this project”.
“While this is a tough decision to take, the urgent need for a vaccine has to be everyone’s priority,” he said.
Other medical experts have also praised the “realistic” decision to abandon the UQ vaccine, saying it reflects the reality of vaccine development.
“In general, about 90% of vaccines never make it to market. As a global community, we have been spoilt with the unprecedented swiftness and success with which the development of Covid-19 vaccines have taken place,” said infectious diseases expert Sanjaya Senanayake from the Australian National University.
What does it mean for Australia?
Australia has all but eliminated community transmission of the virus, after getting on top of outbreaks in recent months.
Prof Murphy said the nation was in a “wonderful position” at present, but there would be “full population coverage” from two vaccines in 2021.
“We don’t need emergency approval – we’re in a good position because we’ve controlled the virus,” he said on Friday.
“So I’m very confident about the successful vaccination strategy that we’ll be facing next year.”
The government said it had prepared for this sort of situation and as such had “spread the risk” with multiple deals for vaccines.
Prime Minister Scott Morrison said focusing Australia’s manufacturing efforts on the other vaccines would mean “we are more likely to have the entire population vaccinated earlier rather than later”.
The Oxford vaccine has been found to be “safe and effective”, according to researchers, but is awaiting approval from regulators around the world.
Early 2021 is still listed as when the first vaccines – most likely from Oxford/AstraZeneca – are scheduled to be given to Australians.
Australia has a population of 25 million people. It recorded just one case of local transmission in the past week.
The nation has reported 908 deaths and 28,000 cases so far during the pandemic – far fewer than many nations.
It has been praised for responding quickly to the pandemic with border shutdowns, lockdown measures and aggressive contract-tracing efforts. Some failures, however, have been blamed for deaths.
Victoria crushed the country’s worst outbreak after four months of a severe lockdown in the state capital, Melbourne.
Read from source: https://www.bbc.com/news/world-australia-55269381
Sydney seaplane crash: Exhaust fumes affected pilot, report confirms
The pilot of a seaplane that crashed into an Australian river, killing all on board, had been left confused and disorientated by leaking exhaust fumes, investigators have confirmed.
The Canadian pilot and five members of a British family died in the crash north of Sydney in December 2017.
All were found to have higher than normal levels of carbon monoxide in their blood, a final report has found.
It recommended the mandatory fitting of gas detectors in all such planes.
British businessman Richard Cousins, 58, died alongside his 48-year-old fiancée, magazine editor Emma Bowden, her 11-year-old daughter Heather and his sons, Edward, 23, and William, 25, and pilot Gareth Morgan, 44. Mr Cousins was the chief executive of catering giant Compass.
The family had been on a sightseeing flight in the de Havilland DHC-2 Beaver plane when it nose-dived into the Hawkesbury River at Jerusalem Bay, about 50km (30 miles) from the city centre.
The final report by the Australian Transport Safety Bureau (ATSB) confirmed the findings of an interim report published in 2020.
It said pre-existing cracks in the exhaust collector ring were believed to have released exhaust gas into the engine bay. Holes left by missing bolts in a firewall then allowed the fumes to enter the cabin.
“As a result, the pilot would have almost certainly experienced effects such as confusion, visual disturbance and disorientation,” the report said.
“Consequently, it was likely that this significantly degraded the pilot’s ability to safely operate the aircraft.”
The ATSB recommended the Civil Aviation Safety Authority consider mandating the fitting of carbon monoxide detectors in piston-engine aircraft that carry passengers.
It previously issued safety advisory notices to owners and operators of such aircraft that they install detectors “with an active warning” to pilots”. Operators and maintainers of planes were also advised to carry out detailed inspections of exhaust systems and firewalls.
Read from source: https://www.bbc.com/news/world-australia-55862128
Australia unlikely to fully reopen border in 2021, says top official
Australia is unlikely to fully open its borders in 2021 even if most of its population gets vaccinated this year as planned, says a senior health official.
The comments dampen hopes raised by airlines that travel to and from the country could resume as early as July.
Department of Health Secretary Brendan Murphy made the prediction after being asked about the coronavirus’ escalation in other nations.
Dr Murphy spearheaded Australia’s early action to close its borders last March.
“I think that we’ll go most of this year with still substantial border restrictions,” he told the Australian Broadcasting Corporation on Monday.
“Even if we have a lot of the population vaccinated, we don’t know whether that will prevent transmission of the virus,” he said, adding that he believed quarantine requirements for travellers would continue “for some time”.
Citizens, permanent residents and those with exemptions are allowed to enter Australia if they complete a 14-day hotel quarantine at their own expense.
Qantas – Australia’s national carrier – reopened bookings earlier this month, after saying it expected international travel to “begin to restart from July 2021.”
However, it added this depended on the Australian government’s deciding to reopen borders.
Australia’s tight restrictions
The country opened a travel bubble with neighbouring New Zealand late last year, but currently it only operates one-way with inbound flights to Australia.
Australia has also discussed the option of travel bubbles with other low-risk places such as Taiwan, Japan and Singapore.
A vaccination scheme is due to begin in Australia in late February. Local authorities have resisted calls to speed up the process, giving more time for regulatory approvals.
Australia has so far reported 909 deaths and about 22,000 cases, far fewer than many nations. It reported zero locally transmitted infections on Monday.
Experts have attributed much of Australia’s success to its swift border lockdown – which affected travellers from China as early as February – and a hotel quarantine system for people entering the country.
Local outbreaks have been caused by hotel quarantine breaches, including a second wave in Melbourne. The city’s residents endured a stringent four-month lockdown last year to successfully suppress the virus.
Other outbreaks – including one in Sydney which has infected about 200 people – prompted internal border closures between states, and other restrictions around Christmas time.
The state of Victoria said on Monday it would again allow entry to Sydney residents outside of designated “hotspots”, following a decline in cases.
While the measures have been praised, many have also criticised them for separating families across state borders and damaging businesses.
Dr Murphy said overall Australia’s virus response had been “pretty good” but he believed the nation could have introduced face masks earlier and improved its protections in aged care homes.
In recent days, Australia has granted entry to about 1,200 tennis players, staff and officials for the Australian Open. The contingent – which has recorded at least nine infections – is under quarantine.
Read from source: https://www.bbc.com/news/world-australia-55699581
Covid: Brisbane to enter three-day lockdown over single infection
The Australian city of Brisbane has begun a snap three-day lockdown after a cleaner in its hotel quarantine system became infected with coronavirus.
Health officials said the cleaner had the highly transmissible UK variant and they were afraid it could spread.
Brisbane has seen very few cases of the virus beyond quarantined travellers since Australia’s first wave last year.
It is the first known instance of this variant entering the Australian community outside of hotel quarantine.
The lockdown is for five populous council areas in Queensland’s state capital.
Premier Annastacia Palaszczuk announced the measure on Friday morning local time, about 16 hours after the woman tested positive.
Ms Palaszczuk said the lockdown aimed to halt the virus as rapidly as possible, adding: “Doing three days now could avoid doing 30 days in the future.”
“I think everybody in Queensland… knows what we are seeing in the UK and other places around the world is high rates of infection from this particular strain,” she said.
“And we do not want to see that happening here in our great state.”
Australia has reported 28,500 coronavirus infections and 909 deaths since the pandemic began. By contrast, the US, which is the hardest-hit country, has recorded more than 21 million infections while nearly 362,000 people have died of the disease.The lockdown will begin at 18:00 on Friday (08:00 GMT) in the Brisbane city, Logan and the Ipswich, Moreton and Redlands local government areas.
Residents will only be allowed to leave home for certain reasons, such as buying essential items and seeking medical care.
For the first time, residents in those areas will also be required to wear masks outside of their homes.
Australia has faced sporadic outbreaks over the past year, with the most severe one in Melbourne triggering a lockdown for almost four months.
A pre-Christmas outbreak in Sydney caused fresh alarm, but aggressive testing and contact-tracing has kept infection numbers low. The city recorded four local cases on Friday.
Prime Minister Scott Morrison’s government has pledged to start mass vaccinations in February instead of March as was planned.
Lockdown interrupts ‘near normal’ life in Brisbane
Simon Atkinson, BBC News in Brisbane
At 8:00 today I popped to the local supermarket for some bread, milk – and because it’s summer here – a mango. I was pretty much the only customer.
When I went past the same shop a couple of hours later it was a different story – 50 people standing in the drizzle – queuing to get inside as others emerged with bulging shopping bags. “Heaps busier than Christmas,” a cheery trolley attendant told me. “It’s off the scale”.
Despite the “don’t panic” messages from authorities, pictures on social media show it’s a pattern being repeated across the city.
While shutdowns are common around the world, the tough and sudden stay-at-home order for Brisbane has caught people on the hop here after months of near normality.
But while such a rapid, hard lockdown off the back of just a single case of Covid-19 will seem crazy in some parts of the world, I’ve not come across too many people complaining.
And I don’t think that’s just because Aussies love to follow a rule. This is the first time the UK variant of the virus has been detected in the community in Australia.
And nobody here wants Brisbane to go through what Melbourne suffered last year. Even if it means going without mangoes.
Read from source: https://www.bbc.com/news/world-australia-55582836
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